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The term oxidative stress, first introduced by Helmut Sies in the late 1980s ( In IBD, evidence suggests that oxidative stress plays a crucial role in the onset and progression of the disease ( Over the past decades, extensive research has been conducted to understand the mechanisms underlying oxidative stress in IBD
These situations highlight how hydrogen water can serve not as a replacement for GR but as a strategic complement, particularly valuable when the GR system faces functional limitations or is overwhelmed by excessive oxidative challenges
Comparing these two trials, after 40 weeks, participants on semaglutide lost an average of 6.9 kg, whereas those on tirzepatide lost 7.8, 10.3, or 12.4 kg, respectively
Box 5 presents recommendations from the consensus panel for HD
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