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DSIP administration did not significantly affect corticotropin-releasing-hormone (CRH)-stimulated or meal-induced ACTH and cortisol secretion, indicating thatcontrary to stress-protective effects reported in some animal studiesDSIP does not measurably blunt the human cortisol response

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The FLOW trial for semaglutide kidney outcomes in T2DM halted due to interim results meeting efficacy criteria FLOW is a RCT comparing injectable semaglutide 1.0 mg with placebo as an adjunct to standard of care on kidney outcomes in people with type 2 diabetes and chronic kidney disease