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The topology of the conformational epitope indicates that binding of the nanobody prevents the conformational change to the postfusion form necessary for membrane fusion, which in turn would explain the neutralizing activity

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FIGURE 3 Berberine increased the expression of PKA, PC1/3, PC2, and Pdx1 In the pancreas, we observed PC1/3 and PC2 under X400 microscope by immunohistochemical method (Figures 4A, B)