Interestingly, GLP-1RA drugs act on receptors that are expressed in brain areas involved in impulse control, reward and addiction potentially explaining their effectiveness in curbing appetite and addiction disorders, said Al-Aly, the director of the Clinical Epidemiology Center at the VA St
If you have questions about GLP-1 medications, changes in your metabolism, or how to manage your energy levels while on these treatments, dont hesitate to reach out
Moreover, this effect can be reversed by specific GLP-1R (exendin-9) antagonists, which means that GLP-1RA may inhibit the proliferation and differentiation of human adipocyte precursors [97,98]
In murine models, the activation of GLP-1 receptors within the VTA has been shown to attenuate the synaptic strength of the VTA-NAcc pathway,154 although GLP-1 receptor expression in VTA neurons is relatively sparse.155 Rat studies indicate that GLP-1 receptor activation in the VTA can enhance dopaminergic neuronal activity via presynaptic mechanisms.156 Despite preclinical evidence and limited clinical trials, the precise influence of GLP-1 receptor stimulation on the effects of abused drugs and alcohol remains unclear
