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We found that males treated with a COX-2 inhibitor, the nodal point in PGE 2 synthesis, during the first 2 days of life have permanently reduced numbers of POA dendritic spines compared with normal males and as adults exhibit little to no male sexual behavior despite normal circulating testosterone levels

Meanwhile, lipid peroxidation and iron colorimetric assays indicated elevated MDA and Fe 2+ concentrations, and reduced GSH concentration and GSH-Px activity in the placenta of PE patients (Fig

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