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In experimental wound healing models, TB-500 treatment increases capillary density by 40-50% while improving functional blood flow restoration, demonstrating translation of cellular angiogenic activity into meaningful tissue-level perfusion benefits

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97 In addition, buforin II B, an AMP derived from histone H2A, can pass through the tumor cell membrane without damage, act on mitochondria, release cytochrome c, and activate the apoptosis protein caspase-9, and induce tumor cell apoptosis in the mitochondrial pathway