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14 Limitations and future perspectives Despite considerable advancements, significant limitations continue to hinder the interpretation and clinical application of probiotic research

In response to lipopolysaccharide stimulation, exendin-4 reduced the expression of IL-1 and TNF- in these cells (85)

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Other van der Waals interactions observed in IgA between Fc and -hairpin 2 are absent in IgM between Fc and -hairpin 2 31 , which could explain the higher flexibility of -hairpin 2 in IgM in comparison to IgA (Supplementary Fig