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When loaded on scaffolds such as collagen sponges and treated dentin matrix (TDM) and subsequently implanted into bone defects, NAC or NAC-pretreated MSCs can significantly enhance collagen deposition, bone formation rate, bone volume/total volume (BV/TV), bone mineral density (BMD) and trabecular bone parameters (thickness, number, separation)
Finally, mechanistic studies showed that the activation of nuclear factor-kappa B (NF-B) was involved in the SGNs damage caused by peroxynitrite and that GPX1 protected SGNs against peroxynitrite-induced damage, at least in part, via blocking the NF-B pathway activation
Additionally, the role of ammonium metabolism in prostate cancer remains underexplored, with insufficient experimental validation of its underlying mechanisms
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