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When a compound average effect is only 2 kilograms over 12 weeks, many individual participants likely saw minimal to no change, while a smaller subset may have responded more strongly, pulling the average up

[3] This is a known effect and not cause for concern

These stubborn areas are characterized by several factors including high alpha-2 adrenergic receptor density relative to beta receptors, reduced blood flow, and greater insulin sensitivity leading to efficient fat storage

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