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10.1126/science.aan3706 99 RowlandI.GibsonG.HeinkenA.ScottK.SwannJ.ThieleI.et al (2018)

Aardvark Therapeutics ARD-101 Aardvarks lead candidate, oral ARD-101 , is a potent pan-agonist of bitter taste receptors (TAS2R) that stimulates enteroendocrine cells in the digestive tract, triggering the release of gut-peptide hormones like GLP-1 and cholecystokinin (CCK), a satiety hormone that activates gut-brain signaling to regulate hunger