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Cuproptosis is associated with major cardiac and vascular diseases, including myocardial ischemia/reperfusion injury, diabetic cardiomyopathy, sepsis-induced cardiac injury, hypertrophic cardiomyopathy, atherosclerotic cardiovascular disease, heart failure, aortic aneurysm, and hypertension

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IP Valuation Impact: The Cubist case establishes a specific diligence requirement: for any asset in active Hatch-Waxman litigation, the financial model must include an explicit patent invalidation scenario with the corresponding generic entry timing