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112 In addition, this uncertain clinical beneficial effect of vitamin C as an antihypertensive agent could be due to the lack of consideration of its pharmacokinetic properties

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[DOI] [PMC free article] [PubMed] [Google Scholar] [160].Blonde L, Russell-Jones D, The safety and efficacy of liraglutide with or without oral antidiabetic drug therapy in type 2 diabetes: an overview of the LEAD 15 studies, Diabetes, obesity & metabolism, 11 Suppl 3 (2009) 2634

The dose is also increased slowly over several months to reduce side effects, so the full effect builds over time rather than arriving at once