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An imbalance in immune homeostasis is created when there are more pro-inflammatory M1-type macrophages than anti-inflammatory M2-type macrophages (Stein et al., 1992

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These alterations promote systemic low-grade inflammation through an imbalance between elevated pro-inflammatory cytokines (e.g., IL-6, TNF-) and anti-inflammatory mediators (e.g., IL-10) (267269)