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To investigate whether QMP would secure a long plasma half-life of a GLP-1 albumin fusion, we constructed a recombinant fusion protein with the identical amino acid sequence as Tanzeum (albiglutide-mimic: GLP-1 WT), as well as a modified version containing the QMP substitutions (GLP-1 QMP) (Fig

The research timeline also highlights an important limitation: long-term data on weight maintenance after discontinuation is still emerging

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The finding that increasing semaglutide exposure is linked to the extent of HbA 1c reduction and weight loss provides further guidance for the ongoing development of GLP-1RAs for the treatment of obesity