To investigate whether the gut microbiome and its metabolites contribute to statin-associated glucose intolerance, we recruited 30 patients with atorvastatin and 10 controls, followed up for 16 weeks, and found a decreased abundance of the genus Clostridium in feces and altered serum and fecal bile acid profiles among patients with atorvastatin therapy
Science 299(5611):14101413 Cuello F, Knaust AE, Saleem U, Loos M, Raabe J, Mosqueira D, Laufer S, Schweizer M, van der Kraak P, Flenner F, Ulmer BM, Braren I, Yin X, Theofilatos K, Ruiz-Orera J, Patone G, Klampe B, Schulze T, Piasecki A, Pinto Y, Vink A, Hbner N, Harding S, Mayr M, Denning C, Eschenhagen T, Hansen A (2021) Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation
Heading up the leadership team is managing director Dr Michael Winlo, who previously worked as CEO of Linear Clinical Research
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