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The trial also showed that GI side effects were "mostly mild to moderate in severity" and were "partially mitigated with a lower starting dose." This means that many of the side effects people try to manage through timing can also be addressed through dose adjustment

Add one sentence: What helped this week? Useful signs of progress include fewer urgent cravings, less eating in secrecy, easier stopping points, fewer Ive ruined it thoughts, more regular meals and fewer days where you force yourself to eat or barely eat

Discussion The relevance of the isoprenaline-induced myocardial infarct is supported by the evidence that catecholamines represent a common pathway in the evolution of myocardial changes in humans who develop myocardial lesions without narrowing or obstruction of coronary arteries [24]

Hopkins JS