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A 2025 preclinical bioRxiv preprint reported that low-dose semaglutide produced cardiac and hepatic benefits independent of weight loss in obese rats with HFpEF, but this is animal data and has not been replicated in humans (bioRxiv preprint, 2025)

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Most common side effects include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and constipation