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PATHOPHYSIOLOGY In the SNc, the two hallmark histopathologic features of PD are depigmentation of dopamine-producing neurons (i.e., loss of SNc neurons) and presence of Lewy bodies (neuronal cytoplasmic filamentous aggregates composed of the presynaptic protein -synuclein) in the remaining SNc neurons
Sau 20 tui, lng cht ny s gim mnh, c bit l khi c th tip xc vi mi trng c hi, nhim
They can then increase the dose to 1030 mg daily [118,119], a dose that can cause some side effects, although very rarely, including nausea, dry mouth, dizziness, headache, and heartburn [120]
PLoS ONE 11:e0159085
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