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GLP-1 suppressed MG-induced beta cell apoptosis through protein kinase A (PKA) and PI3K dependent pathway, respectively It has been reported that activation of GLP-1 receptor by exendin-4 inhibits hydrogen peroxide-induced apoptosis of MIN6 cells in a cAMP- and PI3K-dependent manner with upregulation of Bcl-2/Bcl-xL and downregulation of PARP 19

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Se deficiency negatively impacts immune cells during activation, differentiation, and proliferation through redox signaling, oxidative burst, calcium flux, and the subsequent effector functions of immune cells (Toledo et al., 2020)