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Como parte de las conclusiones del informe, se menciona que la baja persistencia reportada genera interrogantes sobre la viabilidad de invertir en terapias GLP-1 para la obesidad , dado que muchos pacientes no sostienen los beneficios clnicos con el paso del tiempo

Kidney/liver: No routine dose adjustment is typically required, but monitor closelysevere GI effects can cause dehydration and worsen kidney function

GFR in conscious mice was determined via transcutaneously measured elimination kinetics of fluorescein isothiocyanate sinistrin (FITC-sinistrin) (39)

They are a direct pharmacological effect of the glucagon component