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Macrophage polarization defined as the conversion of M2-type macrophages to pro-inflammatory M1-type macrophages, represents a crucial phenotype in the DKD

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Additionally, pinpointing genetic risk factors for ME/CFS will help combat the disbelief some health professionals have towards ME/CFS ( There are also genetic predispositions that render certain individuals susceptible to developing autoimmune diseases (83) and even after Epstein-Barr virus (EBV) infection (84), such as human leukocyte antigen (HLA) variants (84, 85) that have experienced selective pressures whilst co-evolving with pathogens (86, 87)

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