For context, in one study of 175 people with overweight or obesity, participants taking semaglutide: Lost an average of 15 pounds (about 6% of their body weight) within three months Lost an average of 27 pounds (about 11% of their body weight) after six months Recommended lifestyle changes during GLP-1 therapy GLP-1 medications can boost weight loss by increasing satiety and reducing food cravings
If you reach 6-8 weeks on an adequate dose with proper technique and see minimal results, the conversation with your provider should include discussing whether sublingual delivery is providing sufficient bioavailability for your needs, or whether transitioning to injectable administration might be more effective
A meta-analysis of 5 RCTs 42,43,44,45,46 comprising 7,732 adults with T2DM did not observe any effect on cognition, as measured via mini-mental state examination (MMSE) or Montreal cognitive assessment (MoCA), of GLP-1RAs over several months compared with the baseline 38
To microdose brand-name tirzepatide, I see patients resorting to dangerous methods like disassembling the pen or injecting it into a sterile vial to split the dose