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Lee JY, Choo JE, Choi YS, Shim IK, Lee SJ, Seol YJ, et al
In the melanoma model, BPC-157 suppressed Ki-67 expression, a marker associated with cell proliferation, and downregulated VEGF in tumor cells
In conclusion, taken together these data (lack of tolerance development (tolerance studies), prolonged residual anticonvulsive activity, and postponed physical dependence/withdrawal hallmark in diazepam+bpc 157 chronically treated mice) with common benzodiazepines tolerance/withdrawal knowledge, it could be speculated that bpc 157 acts favoring the natural homeostasis of the gaba receptor complex as well as enhancing the gabaergic transmission, and having a mechanism at least partly different from those involved in diazepam tolerance/withdrawal, it may be likely used in further therapy of diazepam tolerance and withdrawal. And also reduces the hyperactivity that occurs when methamphetamine was administered to rats
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