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CT-388 activates both GLP-1 and GIP receptors with a unique signaling profile: Signal-biased dual agonism: Potent cAMP signaling at both GLP-1R and GIPR Minimal to no beta-arrestin recruitment at either receptor Reduced receptor internalization and desensitization Potentially prolonged pharmacological activity GLP-1 receptor activation: Appetite suppression via hypothalamic and brainstem receptors Glucose-dependent insulin secretion Glucagon suppression Gastric emptying delay GIP receptor activation: Additional insulin sensitization Enhanced lipid metabolism Complementary appetite regulation Potential adipose tissue remodeling benefits The biased signaling mechanism is the key differentiator

Repoila, F., Tetart, F., Bouet, J

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Both bariatric surgery and GLP-1 agonist (semaglutide) medications like Ozempic or Wegovy have shown promising results for weight loss