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doi: 10.3389/fonc.2025.1579054 Received 18 February 2025 Accepted 24 March 2025 Published 09 April 2025 Volume 15 - 2025 Edited by Tamer Saad Kaoud, The University of Texas at Austin, United States Reviewed by Luis Enrique Gomez-Quiroz, Autonomous Metropolitan University, Mexico Chuanhui Song, Nanjing University, China Hossein Halimi, Shiraz University of Medical Sciences, Iran Updates Copyright 2025 Lagunas-Rangel

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Any discussion of these medications in a weight-loss context refers to off-label use, which must be evaluated and prescribed by a licensed physician

The substrates for peroxidation reactions during ferroptosis are phospholipids with polyunsaturated fatty acid tails (PL-PUFAs), as they inherently possess intrinsic susceptibility to peroxidation reactions