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In clinical trials, nausea affected roughly 44% of people taking Wegovy and up to 30-40% of tirzepatide users at higher doses

A randomized trial found that low-dose semaglutide significantly decreased: The amount of alcohol consumed during laboratory self-administration tasks 22 Weekly alcohol cravings compared to placebo 22 Drinks per drinking day 22 The magnitude of these effects appears substantial, with medium to large effect sizes for grams of alcohol consumed (, 0.48) and peak breath alcohol concentration (, 0.46) 22

This approach rendered an excellent fit of the raw data, as shown in supplementary Fig