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Therefore, drugs can be selected on the basis of the expression pattern of ferroptosis-inducing genes (e.g., SLC7A11, GSH, and GPX) or genes associated with metabolic pathways that affect ferroptosis (e.g., GLUT, PDK4, glutaminase, VDAC, and G6PD)

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Although not definitively proven, this risk has been a significant concern, particularly with long-term use

Preclinical studies using COPD mouse models revealed that GLP-1RA therapy significantly improved lung function and reduced both morbidity and mortality