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While extensive epidemiological studies have consistently indicated a significant neuroprotective effect, the most conclusive clinical trials in Alzheimers disease have not corroborated this benefit, presenting a critical conundrum for the field

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Il s'agit notamment de la rduction de la synthse et de l'augmentation de l'excrtion du compos par les reins, de la rduction de l'apport alimentaire en raison d'un faible apptit et de la rduction de la consommation d'aliments d'origine animale

This makes the design of new peptides with suitable selectivity profiles a slow and expensive task, relying heavily more or less on trial-and-error approaches