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As of now, research on small molecule GLP-1RAs is still mainly in the laboratory and early clinical trial stages.172 The challenges in developing these drugs include ensuring that they can effectively mimic the biological activity of large molecule GLP-1RAs while maintaining efficacy and selectivity

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GLP-1 receptor agonists GLP-1 became the focus of incretin therapy because of its strong potentiation of glucose-induced insulin secretion and glucose-lowering efficacy in type 2 diabetes

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