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After three weeks, women who received zinc supplements saw significant increases in IGF-1, but only if they were low in it at the start of the study

These actions are germane to fertility as body composition and insulin sensitivity modulate reproductive hormones

Another disappointing outcome arose from the Selenium and Vitamin E Cancer Prevention Trial, which demonstrated that Se (200 g/d from l-selenomethionine (SeMet)), vitamin E, or Se+vitamin E did not prevent prostate cancer in healthy population groups of men in the study and also had no effect on secondary endpoints, which included lung cancer and colorectal cancer ( Reference Lippman, Klein and Goodman 29 )