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It serves two clear functions it confers proteolytic resistance by disrupting normal protease recognition and cleavage at the D-amino acid bond, significantly extending the peptides biological half-life compared to an all-L-amino acid analogue, and it optimises the three-dimensional conformation of the peptide N-terminus for high-affinity binding to the mu-opioid receptor binding pocket

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DSIP is a neuropeptide with a broader, less clearly defined activity profile that, in research, is linked not only to sleep but also to stress and cortisol regulation