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By activating melanocortin receptors, Melanotan 2 enhances melanin production while also supporting appetite control and overall skin pigmentation balance

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GLP-1R activation exerted antifibrotic effects by disrupting the interaction between the NLRP3 inflammasome and PFKFB3-driven glycolysis, and subsequently inhibiting lactate-mediated histone lactylation to reduce the expression of profibrotic genes in activated lung fibroblasts (Fig