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Furthermore, when GSH-pretreated HepG2 cells encounter oxidative stress, GSH potentially plays a hepatoprotective role by activating the signaling pathway related to Nrf2 and hypoxia-1 inducer factor 1, and the expression of GPx, GR, GST, and VEGF, while downregulating the expression of ALT and AST and disease-related pathways, including chemically induced ROS and fibrosis [31]

This accounts for the differences between preformed vitamin A (found in animal foods and supplements) and provitamin A carotenoids like beta carotene

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It has been demonstrated that probiotics can indirectly lower oxidative stress by enhancing gut health and lowering inflammation