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Introduction Oxidative stress is thought to contribute to the development of a wide range of diseases including neurodegenerative (Alzheimer, Parkinson, Amyotrophic Lateral Sclerosis), diabetes, cancer, rheumatoid arthritis, cardiovascular and liver diseases several of them are related with low levels of IGFs such as degenerative and aging disorders [1-8]

The intersections of gut health, microbiome integrity, and medication effects underscore the importance of personalized medicine in this context [6]

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This pathway involves activation of phosphatidylinositol phospholipase C (PI-PLC), phosphatidylinositol 4,5-bisphosphate (PIP 2 ) and inositol trisphosphate (IP 3 ), ultimately resulting in mobilization of intracellular Ca 2+ stores (Camia et al., 2007)