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Figure 3 To determine if the inhibition of proliferation is mediated by impaired DNA or RNA synthesis, we assessed the inhibition of DNA and RNA synthesis by the incorporation of exogenous radioactive thymidine and uridine ( Supplemental Figure 4 )

Serious Adverse Events: Pancreatitis, Thyroid, and Kidney Function Rare but serious side effects include acute pancreatitis (0.1-0.3% in trials), gallbladder issues, and thyroid C-cell tumors in animal models

Many patients start with weekly sessions for 4-6 weeks, then transition to monthly maintenance