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Resting-state functional connectivity (rsFC) analysis will be conducted to assess correlations in blood-oxygen-level-dependent (BOLD) signal fluctuations between different brain regions in the absence of explicit tasks ( Primary outcome The primary outcome is the change in the FTND score at weeks 1, 4, 8, 12, and 24

The histological score was based on the following criteria: integrity and hyperplasia of the lung epithelium (measure of the increase in epithelial thickness), mucus production, lung inflammatory infiltrate (observation of inflammatory infiltrate or nodules), and bronchial smooth muscle remodeling (measure of the increase in smooth muscle thickness)

2 Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy