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If joint pain develops during treatment with retatrutide whether as part of a clinical trial or in any other context a structured and pragmatic approach to management is advisable

10.1016/j.jtemb.2019.03.002 J

Hot flashes the first and last symptoms of menopause Three out of four women experience hot flashes in menopause

HFD inhibits the transcription of key antioxidant genes by triggering NRF2 translocation into obese mouse Tregs nucleus, causing a rapid decline in HO-1 expression in Tregs, leading to enhanced oxidative stress and possible ferroptosis, and causing an intensification of obesity and inflammatory responses (156) ( Figure 3 )