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Furthermore, ketamine alters key signaling pathways, such as the CaMKII-ERK1/2-CREB/NF-B axis, leading to reduced synaptic protein expression, synaptic plasticity impairment, and neurodegeneration (Luo et al., 2021)

O, 24.79 BPC-157 (Body Protection Compound-157) is a bioactive pentadecapeptide that exerts its effects through multiple complementary mechanisms, primarily involving modulation of the nitric oxide (NO) signaling pathway, upregulation of angiogenic factors such as VEGF, and activation of key cell survival and repair pathways including FAKpaxillin and MAPK signaling

Its core mechanisms are closely related to disorders of cellular energy metabolism, accumulation of oxidative stress, and reduced capacity for DNA damage repair

Glutathione also supports immune resilience during periods of heavy physical exertion, when immune resources may be temporarily diverted or suppressed