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Furthermore, its vasodilatory effect may not solely depend on the increase in NO but could also involve other vasoactive substances, such as the reduction of angiotensin II or endothelin-1 activity, which promote vasodilation (162)

A randomized trial in 242 patients with advanced ovarian cancer used six cycles of cyclophosphamide and cisplatin, with or without amifostine pretreatment before each cycle

Notably, the absence of tumor suppressor genes located on chromosome 10, including PTEN, is detected in a considerable portion (30%60%) of non-inherited melanomas

Changes in BBB transport are also evident by a decrease in cerebralspinal fluid to serum ratio of insulin [91, 99]