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Semaglutide as a Pharmacological Strategy for Weight Management Semaglutide, approved for the treatment of obesity in 2021, is a GLP-1RAa class of peptide-based drugs that mimic the effects of the endogenous incretin hormone glucagon-like peptide-1 (GLP-1) [9, 28]

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SIBO has been associated with dysfunctional intestinal motility, characterized by inadequate peristaltic action of gastrointestinal smooth muscle (171174), hypochlorhydria, and pancreatic exocrine insufficiency (175)