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Am J Pathol 140:691707 Alexianu ME, Kozovska M, Appel SH (2001) Immune reactivity in a mouse model of familial ALS correlates with disease progression

Investigations showed a normal chest radiograph/chest X ray (CXR), and spirometry showed moderate obstruction with FEV1 reversibility of 21% (but not back to normal) and even some air-trapping with FVC that improved by 19% with bronchodilator