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Although cytosolic CPS2 can produce a cytosolic pool of carbamoyl phosphate, CPS1 is a major rate-limiting enzyme in pyrimidine biosynthesis using nitrogen released via mitochondrial glutaminolysis 32
These findings are from cell studies and haven't been confirmed in a large human clinical trial, but the mechanistic logic is consistent
Along with significant weight loss, they observed meaningful decreases in serum albumin, vitamin B12, and zinc
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