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The two peptides do not interact negatively when administered concurrently

The Endocrine Society's 2023 Obesity Pharmacotherapy Guidelines note that agents producing greater than 15% weight reduction offer meaningfully better long-term weight maintenance and comorbidity resolution, and encourage clinicians to consider switching when initial therapy produces less than 5% weight reduction at 6 months [17]

Some options on the market under FDA-approval include Wegovy, Saxenda, and Zepbound

Bioidentical progesterone is widely used to counterbalance excess estrogen and is generally considered appropriate when prescribed and monitored by a qualified provider