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The whole situation becomes a real Catch-22 situation

They measured subjective sleep quality more than objective sleep quality They subjectively estimated tiredness Sleep structure was not fully characterized by polysomnography in all studies Data analysis suggested some observed changes were due to issues with the placebo group What is promising about these findings is that statistically significant effects were found in such small sample sizes

Dryn DO, Melnyk MI, Melanaphy D, Kizub IV, Johnson CD, Zholos AV (2023) Bidirectional TRP/L type Ca(2+) channel/RyR/BK(Ca) molecular and functional signaloplex in vascular smooth muscles

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