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The lifestyle interventions should be monitored, adapted, and perpetuated in an informed consent with the patient over the years, regardless of whether additional medical or surgical therapy is started in the course of T2D or obesity ( Incretin-based therapies Incretins are hormones that are secreted from enteroendocrine cells in the gut mucosa after a meal

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Hypothalamic and Endocrine Signaling Beyond stimulating somatotroph cells in the pituitary gland, activation of the GHS-R receptor also influences complex regulatory mechanisms in the hypothalamus

Lizcano F, Guzman G (2014) Estrogen deficiency and the origin of obesity during menopause