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A case-control study found that SLE cases exhibited a statistically significant higher expression of CD40 than controls (p 3.0.CO;2-H 86 BaumannIKolowosWVollREMangerBGaiplUNeuhuberWLet al

Disulfide-linked polymerdrug conjugates and nanocarriers engineered for GSH-triggered drug release have shown favorable safety and preliminary efficacy profiles, highlighting the feasibility of translating redox-responsive strategies into clinical practice [120]

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When glutathione levels drop, the immune system effectively "loses its brakes," allowing for the overproduction of pro-inflammatory cytokines like Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-)