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Recent studies demonstrated that SGLT2i had cardioprotective effects in HFpEF (heart failure with preserved ejection fraction) and HFrEF (heart failure with reduced ejection fraction) with or without diabetes ( 5 Limitations The present study was associated with several limitations

Furthermore, adipose insulin resistance facilitates the release of adipokines (such as adiponectin, leptin, and resistin) and cytokines (like TNF-, IL-6 and IL-1) leading to chronic inflammation and hyperglycemia

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