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I read the FDA statement, but it was very blank

This analysis may be superseded by an updated publication on the same topic

PMC 3384081

However, subgroup analyses from the TOPCAT clinical trial indicated that patients enrolled from the Americas, where adherence to therapy was higher, experienced notably higher rates of hyperkalemia compared to those from Russia and Georgiasupporting the hypothesis that increased exposure to spironolactone may have contributed to the regional differences in adverse event profiles [56]