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Overall, the results suggest that RRM2 acts as a pro-oncogenic molecule and may promote the progression of PTC by activating the PI3K/Akt signaling pathway, regulating key proteins of the cell cycle, and inducing the EMT process, which is in high agreement with previous findings in other malignant tumors

Nausea, vomiting, diarrhea, constipation, and abdominal pain were mainly transient and mild to moderate in severity

Considerations for the future of obesity drug development Today, the focus is on weight loss, and of course that is the primary read-out in many clinical trials