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These new anticoagulant therapies are associated with fewer bleeding events than traditional anticoagulant drugs and the effects of contact system activation could be suppressed by direct inhibition of FXII, FXI and thrombin

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Neuro Endocrinol Lett 32:13340, PMID: 21552194 Kaddurah-Daouk R, Yuan P, Boyle SH, Matson W, Wang Z, Zeng ZB, Zhu H, Dougherty GG, Yao JK, Chen G, Guitart X, Carlson PJ, Neumeister A, Zarate C, Krishnan RR, Manji HK, Drevets W (2012) Cerebrospinal fluid metabolome in mood disorders-remission state has a unique metabolic profile